The mechanism of cytostatic effect of a new somatostatin analog cifetrelin on in vitro cultured MCF-7 breast carcinoma cells.

Autor: Mikhaevich EI; N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, Russia. meldo@mail.ru, Krasil'nikov MA
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Mar; Vol. 154 (5), pp. 669-72.
DOI: 10.1007/s10517-013-2026-3
Abstrakt: The mechanisms of antitumor effect of cifetrelin have been studied in vitro on cultured MCF-7 breast carcinoma cells. Cifetrelin exhibits higher cytotoxic activity than native somatostatin. In subthreshold concentrations, cifetrelin boosts the apoptotic effects of drugs, e.g. adriamycin. Cifetrelin-induced apoptosis develops by the p53-independent mechanism and is associated with early suppression of NF-kappaB activity. These data attest to high antitumor activity of cifetrelin.
Databáze: MEDLINE
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