| Autor: |
Koolen HH; a Department of Chemistry , University of Amazonas , Manaus , 69077000 , Brazil., Soares ER, da Silva FM, de Oliveira AA, de Souza AQ, de Medeiros LS, Rodrigues-Filho E, Cavalcanti BC, Pessoa CO, Moraes MO, Salvador MJ, de Souza AD |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2013; Vol. 27 (22), pp. 2118-25. Date of Electronic Publication: 2013 May 09. |
| DOI: |
10.1080/14786419.2013.793685 |
| Abstrakt: |
A new dammarane triterpene named mauritic acid (1) was isolated from the roots of Mauritia flexuosa L.f. The complete structural assignment of this new compound was elucidated from spectroscopic methods. Moreover, this compound was evaluated for its cytotoxicity against human cancer cell lines (OVCAR-8, PCM3, NCIH358M and different leukaemia cell strains). The mauritic acid presented significant cytotoxicity against OVCAR-8, PCM3 and NCIH358M cell lines with IC50 3.02, 2.39 and 6.19 μM, respectively. The triterpenes 1 and 2 were also tested for their antimicrobial activity against 15 strains of microorganisms, including fungi and bacteria, with the best minimal inhibitory concentration values ranging from 50.8 to 203.5 μM. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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