Variants of cardiomyopathy and hypertension in neuroblastoma.

Autor: Kwok SY; Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong., Cheng FW, Lo AF, Leung WK, Yam MC, Li CK
Jazyk: angličtina
Zdroj: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2014 Apr; Vol. 36 (3), pp. e158-61.
DOI: 10.1097/MPH.0b013e318290c628
Abstrakt: Catecholamine-associated cardiomyopathies caused by neuroblastoma have rarely been reported. We are reporting 2 cases of neuroblastoma associated with hypertension and severe cardiomyopathic changes in different extremes. One case was dilated cardiomyopathy with heart failure, and the other showed echocardiographic features simulating hypertrophic obstructive cardiomyopathy. Both girls had high levels of urine catecholamines on presentation. Anthracycline group of chemotherapy was avoided. Chemotherapy and tumor resection resulted in successful normalization of blood pressure and regression of cardiomyopathic changes. Blood pressure and cardiomyopathic changes should be monitored not only at presentation, but also during the treatment for neuroblastoma.
Databáze: MEDLINE