| Autor: |
Zverinskiĭ IV, Mel'nichenko NG, Poplavskiĭ VA, Sut'ko IP, Telegin PG, Shliakhtun AG |
| Jazyk: |
ruština |
| Zdroj: |
Biomeditsinskaia khimiia [Biomed Khim] 2013 Jan-Feb; Vol. 59 (1), pp. 90-6. |
| Abstrakt: |
On the eighth day after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injection of berberine (10 mg/kg) for 6 days caused a partial normalization of permeability of hepatocytes plasma membranes and activity microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. Membrane-stabilizing effect of berberine is probably realized at the level of inhibition of prooxidant status of liver cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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