Very-high-dose methadone with minimal toxicity and inadequate pain control in a hospice patient with cancer.

Autor: Latuga NM; The Center for Hospice and Palliative Care, 225 Como Park Boulevard, Cheektowaga, NY 14227, USA. nlatugarx@gmail.com, Wahler RG
Jazyk: angličtina
Zdroj: Journal of pain & palliative care pharmacotherapy [J Pain Palliat Care Pharmacother] 2013 Jun; Vol. 27 (2), pp. 143-9. Date of Electronic Publication: 2013 May 06.
DOI: 10.3109/15360288.2013.786011
Abstrakt: A case is reported of a 48-year-old Caucasian male who was admitted to hospice care with metastatic cancer of the larynx. The patient required very high methadone doses and experienced little opioid toxicity. The pharmacodynamics and pharmacokinetics of methadone are discussed in the context of this patient experience.
Databáze: MEDLINE