| Autor: |
Stojadinovic A; Walter Reed Army Medical Center, Department of Surgery, 6900 Georgia Avenue NW, Washington, DC 20307, USA., Elster E, Potter BK, Davis TA, Tadaki DK, Brown TS, Ahlers S, Attinger CE, Andersen RC, Burris D, Centeno J, Champion H, Crumbley DR, Denobile J, Duga M, Dunne JR, Eberhardt J, Ennis WJ, Forsberg JA, Hawksworth J, Helling TS, Lazarus GS, Milner SM, Mullick FG, Owner CR, Pasquina PF, Patel CR, Peoples GE, Nissan A, Ring M, Sandberg GD, Schaden W, Schultz GS, Scofield T, Shawen SB, Sheppard FR, Stannard JP, Weina PJ, Zenilman JM |
| Jazyk: |
angličtina |
| Zdroj: |
Military medicine [Mil Med] 2010 Jul; Vol. 175 (7 Suppl), pp. 18-24. |
| DOI: |
10.7205/milmed-d-10-00156 |
| Abstrakt: |
The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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