| Autor: |
Peresi E; Tropical Disease Department, Botucatu School of Medicine, UNESP, São Paulo State University, Botucatu, SP, Brazil ; Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu, UNESP, Rubião Júnior S/N, Botucatu 18618-970, SP, Brazil., Oliveira LR, da Silva WL, da Costa EA, Araujo JP Jr, Ayres JA, Fortes MR, Graviss EA, Pereira AC, Calvi SA |
| Jazyk: |
angličtina |
| Zdroj: |
Tuberculosis research and treatment [Tuberc Res Treat] 2013; Vol. 2013, pp. 285094. Date of Electronic Publication: 2013 Mar 27. |
| DOI: |
10.1155/2013/285094 |
| Abstrakt: |
Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN- γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF -308 A allele with higher TNF- α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 -819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF- β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 -819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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