Feline sporotrichosis: histopathological profile of cutaneous lesions and their correlation with clinical presentation.

Autor: Miranda LH; Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil, 4365, Rio de Janeiro 21040-360, Brazil. luisahmiranda@gmail.com, Conceição-Silva F, Quintella LP, Kuraiem BP, Pereira SA, Schubach TM
Jazyk: angličtina
Zdroj: Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2013 Jul; Vol. 36 (4), pp. 425-32. Date of Electronic Publication: 2013 Apr 25.
DOI: 10.1016/j.cimid.2013.03.005
Abstrakt: Cutaneous lesions of feline sporotrichosis show high fungal load and are associated with severe disease and elevated zoonotic potential. The present study describes the histopathology and fungal load of the lesions in different clinical presentations of feline sporotrichosis. Cats with sporotrichosis were separated into groups L1, L2 and L3 (lesions in one, two and three or more locations, respectively) and subjected to skin biopsies for histopathology. Eighty-six cats were included in the study. Lesions were suppurative granulomatous in 84 cases and poorly formed granulomas were predominant. The well-formed granulomas were associated with group L1. The high fungal load was predominant in group L3 and in poorly formed granuloma cases and did not occur in well-formed granulomas cases. The good general condition was associated with low fungal load. These findings suggest that the fungal load control in animals with more localized lesions and well-organized response is linked with the improvement in the outcome of infected cats.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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