Lower fibroblast growth factor 23 levels in young adults with Crohn disease as a possible secondary compensatory effect on the disturbance of bone and mineral metabolism.

Autor:	Oikonomou KA; Department of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece; Institute for Biomedical Research & Technology (BIOMED), Centre for Research and Technology-Thessaly (CERETETH), Larissa, Greece., Orfanidou TI; Institute for Biomedical Research & Technology (BIOMED), Centre for Research and Technology-Thessaly (CERETETH), Larissa, Greece., Vlychou MK; Department of Radiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. Electronic address: mvlychou@med.uth.gr., Kapsoritakis AN; Department of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece., Tsezou A; Institute for Biomedical Research & Technology (BIOMED), Centre for Research and Technology-Thessaly (CERETETH), Larissa, Greece; Department of Biology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece., Malizos KN; Institute for Biomedical Research & Technology (BIOMED), Centre for Research and Technology-Thessaly (CERETETH), Larissa, Greece; Department of Orthopaedics, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece., Potamianos SP; Department of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Jazyk:	angličtina
Zdroj:	Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2014 Jan-Mar; Vol. 17 (1), pp. 177-84. Date of Electronic Publication: 2013 Apr 25.
DOI:	10.1016/j.jocd.2013.03.019
Abstrakt:	Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal axis. Serum FGF-23 concentrations, as well as various other laboratory parameters involved in bone homeostasis, were measured and analyzed with regard to various diseases and patients' characteristics in 44 patients with Crohn disease (CD) and 20 healthy controls (HCs) included in this cross-sectional study. Serum FGF-23 levels were significantly lower in patients with CD (900.42 ± 815.85pg/mL) compared with HC (1410.94 ± 1000.53pg/mL), p = 0.037. Further analyses suggested FGF-23 as a factor independent from various parameters including age (r = -0.218), body mass index (r = -0.115), 25-hydroxy vitamin D (r = 0.126), parathyroid hormone (r = 0.084), and bone mineral density (BMD) of hip and lumbar (r = 0.205 and r = 0.149, respectively). This observation remained even after multivariate analyses, exhibiting that BMD was not affected by FGF-23, although parameters such as age (p = 0.026), cumulative prednisolone dose (p < 0.0001), and smoking status (p = 0.024) were strong determinants of BMD regarding hip. Lower FGF-23 levels in patients with bowel inflammation are accompanied but not directly correlated with lower vitamin D levels, showing no impact on BMD determination of young adults with CD. The downregulation of serum FGF-23 levels in CD appears as a secondary compensatory effect on the bone and mineral metabolism induced by chronic intestinal inflammation. (Copyright © 2014 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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