Injection of specific amyloid-beta oligomers (beta₁₋₄₀:beta₁₋₄₂ = 10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis.
| Autor: | Ozdemir MB; Pamukkale University, Denizli, Turkey., Erdogan C, Iwasaki K, Watanabe T, Ishikane S, Fujiwara M |
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| Jazyk: | angličtina |
| Zdroj: | Neurological research [Neurol Res] 2013 Oct; Vol. 35 (8), pp. 798-803. Date of Electronic Publication: 2013 Apr 23. |
| DOI: | 10.1179/1743132813Y.0000000195 |
| Abstrakt: | Objectives: Because of the well-known neurochemical interactions between the septum and hippocampus during memory processes, we investigated the effect of amyloid-beta (A-beta) injection into the medial septum (MS) on the behavior in Wistar rats. We also assessed whether the observed effects were functional or due to apoptosis. Methods: Specific A-beta oligomers (beta1-40:beta1-42 = 10:1) were injected into MS for seven consecutive days. Behavior was assessed with the Morris water maze task. Results: Compared with the control group, rats that received A-beta oligomers exhibited significant memory retention impairment (P < 0·05) without apoptosis in the cornu ammonis (CA)1 and CA3 regions of the dorsal hippocampus. Discussion: These data indicate that septal injection of A-beta impairs memory retention, even in the absence of hippocampal apoptosis. This result might bring new insight to spatial memory-related disorders like Alzheimer's disease (AD). |
| Databáze: | MEDLINE |
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