| Abstrakt: |
The 1,4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel modulating agents and have experienced widespread use in the treatment of cardiovascular disease which include antihypertensive, antianginal, vasodilator and cardiac depressants activities. It also shows antibacterial, anticancer, antileishmanial, anticoagulant, anticonvulsant, antitubercular, antioxidant, antiulcer, CFTR, antimalarials, neuroprotection properties, HIV-1 protease inhibitors, antifertility activities and many more. There are many marketed drugs which contain 1,4-dihydropyridines ring as basic scaffold. In this review, attempts have been made to disclose various therapeutic applications of 1,4-dihydropyridine derivatives which have been reported during the period of 2001-2011. |
