[Possibility of the development of non-transfusion hemosiderosis in beta-thalassemia, caused by association with HLA-linked hemochromatosis].

Autor: Settarova DA, Donskov SI, Manishkina RP, Krasavtseva TK, Klinika EG
Jazyk: ruština
Zdroj: Gematologiia i transfuziologiia [Gematol Transfuziol] 1990 Mar; Vol. 35 (3), pp. 16-8.
Abstrakt: The data of HLA-haplotyping were used as an allele marker controlling hereditary hemochromatosis in 23 patients with beta-thalassemia. The results obtained have permitted a conclusion that hemosiderosis in patients with beta-thalassemia may be caused by association of beta-thalassemia gene with hereditary hemochromatosis. Early diagnosis of hyperferremia is of great prognostic importance as the adequate treatment timely conducted can prevent the development of irreversible changes in the patients.
Databáze: MEDLINE