Effects of oral 5-hydroxytryptophan on a standardized planning task: insight into possible dopamine/serotonin interactions in the forebrain.
| Autor: | Gendle MH; Department of Psychology, Elon University, Elon, NC 27244, USA. mgendle@elon.edu, Young EL, Romano AC |
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| Jazyk: | angličtina |
| Zdroj: | Human psychopharmacology [Hum Psychopharmacol] 2013 May; Vol. 28 (3), pp. 270-3. Date of Electronic Publication: 2013 Apr 22. |
| DOI: | 10.1002/hup.2314 |
| Abstrakt: | Objective: Several studies have suggested that exogenous administration of the serotonin precursor 5-hydroxytryptophan (5-HTP) can result in the ectopic production of serotonin in dopaminergic neurons and a concomitant reduction in dopamine release. This study tested this hypothesis using the Tower of London (TOL), a test of planning and executive control that is sensitive to changes in forebrain dopamine activity, but insensitive to alterations in serotonin. Methods: A sample of 68 undergraduates participated, and each received either three 50-mg 5-HTP capsules or placebos, and completed the TOL following a set absorption period. Results: 5-HTP significantly lengthened the average time needed to complete each of the 10 trials of the TOL. 5-HTP did not affect accuracy on this task. Conclusions: Oral exogenous 5-HTP disrupts dopaminergic function in the human forebrain. (Copyright © 2013 John Wiley & Sons, Ltd.) |
| Databáze: | MEDLINE |
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