Virulence modulation of Streptococcus mutans biofilms by metal ions released from orthodontic appliances.
| Autor: | Rymovicz AU; a PhD student, Xenobiotics Research Unit, The Pontifical Catholic University of Paraná, Curitiba, Brazil., Ronsani MM, Grégio AM, Guariza-Filho OG, Tanaka O, Rosa EA |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Angle orthodontist [Angle Orthod] 2013 Nov; Vol. 83 (6), pp. 987-93. Date of Electronic Publication: 2013 Apr 15. |
| DOI: | 10.2319/112712-904.1 |
| Abstrakt: | Objectives: To evaluate the impact of metal ions commonly shed from orthodontic appliances on the virulence of Streptococcus mutans ATCC®25175™ biofilms. Materials and Methods: Biofilms were grown in the presence of Ni(2+), Fe(3+), Cr(3+), Co(2+), and a metal ion pool at concentrations similar to those released in saliva of orthodontic patients for 72 hours. Once mature, biofilms were treated for up to 12 hours with 5% glucose. Results: Ions interfered with the growth of S mutans by reducing its biomass (Ni(2+), Fe(3+), Cr(3+)), raising its rates of sugar metabolism (Ni(2+), Fe(3+), Cr(3+)), and raising its secretion of lactate (Ni(2+), Fe(3+), Cr(3+), pool). Conclusion: The laboratory data presented here point to the possibility of virulence increase of S mutans by metal ions commonly released during orthodontic therapy. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|