Differences in clinical profile of African-American women with peripartum cardiomyopathy in the United States.

Autor: Goland S; Department of Cardiology, Kaplan Medical Center, Rehovot, Israel., Modi K, Hatamizadeh P, Elkayam U
Jazyk: angličtina
Zdroj: Journal of cardiac failure [J Card Fail] 2013 Apr; Vol. 19 (4), pp. 214-8.
DOI: 10.1016/j.cardfail.2013.03.004
Abstrakt: Background: Peripartum cardiomyopathy (PPCM) is a rare and heterogeneous disease with a higher prevalence in African Americans (AAs) in the USA. The clinical features and prognosis of PPCM in AAs have not been sufficiently characterized.
Methods: We studied 52 AA patients with PPCM and compared clinical characteristics and outcome with those of 104 white patients.
Results: AA patients were significantly younger (26 ± 7 vs 30 ± 6 years; P < .001), had a higher prevalence of gestational hypertension (61% vs 41%; P = .03), and were diagnosed more commonly postpartum rather then antepartum (83% vs 64%; P = .03). The rate of left ventricular (LV) recovery (LV ejection fraction [LVEF] ≥50%) was significantly lower in AAs (40% vs 61%; P = .02). AA women also had a larger LV end-diastolic diameter (57 ± 10 vs 51 ± 6 mm; P = .004) as well as lower LVEF (40% ± 16.7% vs 46% ± 14%; P = .002) at the last follow-up. Moreover, AA patients had a significantly higher incidence of the combined end points of mortality and cardiac transplantation (P = .03) and showed a strong trend (P = .09) for increased mortality.
Conclusions: AA patients with PPCM in the USA have a different clinical profile and worse prognosis compared with white patients. Further research to evaluate potentially correctable causes for these differences is warranted.
(Copyright © 2013 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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