No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment.

Autor: Bras AE; Department of Immunology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., van den Heuvel-Eibrink MM, van der Sluijs-Gelling AJ, Coenen EA, Wind H, Zwaan CM, te Marvelde JG, van der Burg M, Gibson B, Rijneveld AW, de Haas V, van Dongen JJ, van der Velden VH
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2013 Jun; Vol. 161 (6), pp. 861-4. Date of Electronic Publication: 2013 Apr 12.
DOI: 10.1111/bjh.12329
Abstrakt: B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.
(© 2013 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: