| Autor: |
Dulla B; Institut für Organische Chemie, Universität Regensburg, Universitäts str. 31, 93053 Regensburg, Germany., Kirla KT, Rathore V, Deora GS, Kavela S, Maddika S, Chatti K, Reiser O, Iqbal J, Pal M |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2013 May 21; Vol. 11 (19), pp. 3103-7. Date of Electronic Publication: 2013 Apr 10. |
| DOI: |
10.1039/c3ob40217g |
| Abstrakt: |
A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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