The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice.
| Autor: | Ajayi SA; Department of Anatomy, College of Health Sciences, Osun State University, Osogbo Osun State., Ofusori DA, Ojo GB, Ayoka OA, Abayomi TA, Tijani AA |
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| Jazyk: | angličtina |
| Zdroj: | Asian Pacific journal of tropical biomedicine [Asian Pac J Trop Biomed] 2011 Aug; Vol. 1 (4), pp. 261-5. |
| DOI: | 10.1016/S2221-1691(11)60039-7 |
| Abstrakt: | Objective: To assess the neuroprotective effects of aqueous extract of Garcinia kola on neurotoxin administered malnourished mice adopting histological procedure. Methods: The study was carried out using thirty-two adult malnourished mice which were randomly assigned into four groups (n=8): A, B, C and D. Group A served as control, while the other groups served as the experimental groups. Animals in group A were fed malnourished diet ad libitum and given water liberally. Animals in group B were administered with 3-Nitropropionic acid (3-NP) (neurotoxin) only at 20 mg/kg body weight, group C were given only Garcinia kola extracts, and group D were pre-treated with Garcinia kola extracts at 200 mg/kg for seven days prior to administration of neurotoxin at 20 mg/kg body weight. After three days of neurotoxins administration in the relevant groups, the brains were excised and fixed in formal calcium for histological processing. Results: The study showed that hippocampal and cerebellar neurons of animals in group B exhibited some cellular degeneration and blood vessel blockage, which were not seen in groups A, C and D. Cresyl violet staining was least intense in group B than in groups A, C and D. Despite the fact that animals in group D has equal administration of 3-Nitropropionic acid concentration, there were no traces of neural degeneration as it was evidenced in group B. Conclusions: It is concluded that Garcinia kola has protective effects on the neurons of the hippocampus and cerebellum of malnourished mice. |
| Databáze: | MEDLINE |
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