Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage.

Autor: Bing SJ; Department of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University, Ara-dong 1, Jeju 690-756, South Korea., Ha D, Kim MJ, Park E, Ahn G, Kim DS, Ko RK, Park JW, Lee NH, Jee Y
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2013 Jul; Vol. 57, pp. 147-53. Date of Electronic Publication: 2013 Mar 26.
DOI: 10.1016/j.fct.2013.03.022
Abstrakt: Gamma ray irradiation triggers DNA damage and apoptosis of proliferating stem cells and peripheral immune cells, resulting in the destruction of intestinal crypts and lymphoid system. Geraniin is a natural compound extracts from an aquatic plant Nymphaea tetragona and possesses good antioxidant property. In this study, we demonstrate that geraniin rescues radiosensitive splenocytes and jejunal crypt cells from radiation-induced DNA damage and apoptosis. Isolated splenocytes from C57BL/6 mice treated with geraniin were protected against radiation injury of 2 Gy irradiation through the enhancement of the proliferation and attenuation of DNA damage. Also, geraniin inhibited apoptosis in radiosensitive splenocytes by reducing the expression level and immunoreactivity of proapoptotic p53 and Bax and increasing those of anti-apoptotic Bcl-2. In mice exposed to radiation, geraniin treatment protected splenocytes and intestinal crypt cells from radiation-induced cell death. Our results suggest that geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Therefore, geraniin can be a radioprotective agent against γ-irradiation exposure.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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