Toxic epidermal necrolysis induced by lansoprazole.

Autor: Fracaroli TS; Dermatology at the Teaching Hospital, State University of Rio de Janeiro (Hospital Universitário Pedro Ernesto – Universidade do Estado do Rio de Janeiro - HUPE-UERJ), Rio de Janeiro, (RJ), Brazil. tsfracaroli@yahoo.com.br, Miranda LQ, Sodré JL, Chaves M, Gripp A
Jazyk: angličtina
Zdroj: Anais brasileiros de dermatologia [An Bras Dermatol] 2013 Jan-Feb; Vol. 88 (1), pp. 117-20.
DOI: 10.1590/s0365-05962013000100018
Abstrakt: Toxic epidermal necrolysis is a rare, severe cutaneous reaction, mostly caused by drugs. It affects the skin and mucous membranes, with involvement of more than 30% of body surface. We describe the case of a young woman, previously healthy, who developed skin detachment of more than 90% of the body surface 15 days after being administered lansoprazole for peptic disease. The treatment consisted in discontinuation of the drug involved and early administration of intravenous human immunoglobulin, which led to a satisfactory outcome of the case, substantiating the impact of early diagnosis and treatment on the morbidity and mortality of these patients.
Databáze: MEDLINE