Evaluation of psychoacoustic tests and P300 event-related potentials in elderly patients with hyperhomocysteinemia.
| Autor: | Díaz-Leines S; Departamento de Patología del Lenguaje y Procesamiento Central Auditivo, Instituto Nacional de Rehabilitación, México DF, México. serch_dl@hotmail.com, Peñaloza-López YR, Serrano-Miranda TA, Flores-Ávalos B, Vidal-Ixta MT, Jiménez-Herrera B |
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| Jazyk: | English; Spanish; Castilian |
| Zdroj: | Acta otorrinolaringologica espanola [Acta Otorrinolaringol Esp] 2013 Jul-Aug; Vol. 64 (4), pp. 265-72. Date of Electronic Publication: 2013 Mar 23. |
| DOI: | 10.1016/j.otorri.2013.01.006 |
| Abstrakt: | Introduction and Objectives: Hyperhomocysteinemia as a risk factor for hearing impairment, neuronal damage and cognitive impairment in elderly patients is controversial and is limited by the small number of studies. The aim of this work was determine if elderly patients detected with hyperhomocysteinemia have an increased risk of developing abnormalities in the central auditory processes as compared with a group of patients with appropriate homocysteine levels, and to define the behaviour of psychoacoustic tests and long latency potentials (P300) in these patients. Methods: This was a cross-sectional, comparative and analytical study. We formed a group of patients with hyperhomocysteinemia and a control group with normal levels of homocysteine. All patients underwent audiometry, tympanometry and a selection of psychoacoustic tests (dichotic digits, low-pass filtered words, speech in noise and masking level difference), auditory evoked brainstem potentials and P300. Results: Patients with hyperhomocysteinemia had higher values in the test of masking level difference than did the control group (P=.049) and more protracted latency in P300 (P=.000). Conclusions: Hyperhomocysteinemia is a factor that alters the central auditory functions. Alterations in psychoacoustic tests and disturbances in electrophysiological tests suggest that the central portion of the auditory pathway is affected in patients with hyperhomocysteinemia. (Copyright © 2012 Elsevier España, S.L. All rights reserved.) |
| Databáze: | MEDLINE |
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