[Home-based zoledronic acid infusion therapy in patients with solid tumours: compliance and patient-nurse satisfaction].
| Autor: | Lebret T; Hôpital Foch, service d'urologie, Université de Versailles-Saint-Quentin-en-Yvelines, 40, rue Worth, BP 36, 92151 Suresnes cedex, France. t.lebret@hopital-foch.org, Mouysset JL, Lortholary A, Kouri CE, Bastit L, Ktiouet M, Khemaies S, Murraciole X, Guérif S |
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| Jazyk: | francouzština |
| Zdroj: | Bulletin du cancer [Bull Cancer] 2013 Mar; Vol. 100 (3), pp. 247-57. |
| DOI: | 10.1684/bdc.2013.1713 |
| Abstrakt: | Purpose: To explore patient and nurse satisfaction, compliance with best practice, technical feasibility and safety of home infusion of a bisphosphonate. Methods: Prospective 1-year survey of home zoledronic acid therapy (4 mg, 15-min intravenous, every three to four weeks) in patients with bone metastases secondary to a solid malignancy. A physician questionnaire, nurse satisfaction/feasibility questionnaire and patient satisfaction questionnaire were administered. Results: Physician participation rate: 56.5% (87/154); 818 patients included; 381 predominantly community nurses; 763/788 case report forms meeting inclusion criteria. Patient Characteristics: median age, 68 years (30-95); M/F, 40/60; ECOG-PS 0 or 1, 78.6%; primary tumour site: breast (55.2%), prostate (28.4%), lung (7.2%), other (9.4%). Nurse satisfaction rates: 90.9% (organization of home ZOL therapy); 96.7% (ease of infusion); 97.5% (patient-nurse relationship); 73% (relationship with hospital staff). Patient satisfaction rates: 95.3% overall; 57.6% (quality of the nurse-patient relationship); 68.8% (less travel/waiting); 52.9% (consideration for home environment). Treatment tolerance: 33.63% (discontinuation due to adverse events); 0.6% (osteonecrosis of the jaw); 0.2% fractures. Practitioner compliance with best practice: 76.7% to 83.7% (recommended and/or tolerated dosage), 73% (dental hygiene checks at inclusion; 48 to 56% thereafter); 66% (pre-infusion hydration); often undocumented for calcium/vitamin D supplementation. Conclusion: Home zoledronic acid treatment was well tolerated. There was a very high level of both patient and nurse satisfaction with home therapy. However, better compliance with best practice should be encouraged. |
| Databáze: | MEDLINE |
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