| Autor: |
Quistad GB; Sandoz Crop Protection Corporation, Palo Alto, California 94304., Suwanrumpha S, Jarema MA, Shapiro MJ, Skinner WS, Jamieson GC, Lui A, Fu EW |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1990 May 31; Vol. 169 (1), pp. 51-6. |
| DOI: |
10.1016/0006-291x(90)91431-q |
| Abstrakt: |
The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsis aperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins (AG489, AG505, and AG452) contain 1, 5, 9, 13, 18, 22-hexaazadocosane which is unique as a natural polyamine because of its length and hydroxylation at the 5-aza position. The polyamine portions of two other alpha-agatoxins (AG488 and AG504) are unusual also, containing guanidinooxy moieties. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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