The role of triglyceride lipases in cancer associated cachexia.
| Autor: | Das SK; Institute of Pathology, Medical University of Graz, 8036 Graz, Austria., Hoefler G |
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| Jazyk: | angličtina |
| Zdroj: | Trends in molecular medicine [Trends Mol Med] 2013 May; Vol. 19 (5), pp. 292-301. Date of Electronic Publication: 2013 Mar 14. |
| DOI: | 10.1016/j.molmed.2013.02.006 |
| Abstrakt: | Cancer associated cachexia (CAC) is a complex multiorgan syndrome frequently associated with various forms of cancer. Affected patients suffer from a dramatic loss of skeletal muscle and adipose tissue. Most cases are accompanied by anorexia, and nutritional supplements are not sufficient to stop or reverse its course. CAC impairs many forms of therapeutic interventions and accounts for 15-20% of all deaths of cancer patients. Recently, several studies have recognized the importance of lipid metabolism and triglyceride hydrolysis as a major metabolic pathway involved in the initiation and/or progression of CAC. In this review, we explore the contributions of the triglyceride lipases to CAC and discuss various factors modulating lipase activity. (Copyright © 2013 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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