Duration of cisplatin excretion in breast milk.

Autor: Hays KE; 1Department of Pharmacy, University of Washington, Seattle, WA, USA., Ryu RJ, Swisher EM, Reed E, McManus T, Rybeck B, Petros WP, Hebert MF
Jazyk: angličtina
Zdroj: Journal of human lactation : official journal of International Lactation Consultant Association [J Hum Lact] 2013 Nov; Vol. 29 (4), pp. 469-72. Date of Electronic Publication: 2013 Mar 14.
DOI: 10.1177/0890334413479671
Abstrakt: Cisplatin, a platinum-based chemotherapy agent, is commonly used in treating cancers that may affect women of childbearing age, including cervical cancer, triple-negative breast cancer, and pediatric tumors in adolescents. The authors found that platinum was undetectable in breast milk at 66 hours and beyond following a 70-mg dose of intravenous cisplatin. Relative infant dose of platinum was calculated to be between 0.29% and 0.40% of the maternal dose corrected for body weight. This case demonstrates minimal exposure to platinum via breast milk, following a single 70-mg intravenous dose of cisplatin.
Databáze: MEDLINE