TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians.

Autor:	Chew CS; School of Pathology and Laboratory Medicine, University of Western Australia, Western Australia, Australia., Wadley AL, Lombard Z, Kamerman PR, Price P
Jazyk:	angličtina
Zdroj:	Genes and immunity [Genes Immun] 2013 Jun; Vol. 14 (4), pp. 268-70. Date of Electronic Publication: 2013 Mar 14.
DOI:	10.1038/gene.2013.8
Abstrakt:	Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies.
Databáze:	MEDLINE
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