| Autor: |
Murdoch FR; School of Veterinary and Clinical Sciences, Murdoch University, Perth, Western Australia. frasermurdoch@hotmail.com, Maker GL, Nitsos I, Polglase GR, Musk GC |
| Jazyk: |
angličtina |
| Zdroj: |
Laboratory animals [Lab Anim] 2013 Jan; Vol. 47 (1), pp. 66-70. |
| DOI: |
10.1177/0023677212473712 |
| Abstrakt: |
The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 µL/h (3 µg/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels. Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group. Delivery of 3 µg/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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