Multicentre results of stereotactic body radiotherapy for secondary liver tumours.

Autor: Berber B; Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Ibarra R; Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Snyder L; Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Yao M; Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Fabien J; Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Milano MT; Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA., Katz AW; Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA., Goodman K; Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Stephans K; Department of Radiation Oncology, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA., El-Gazzaz G; Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA., Aucejo F; Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA., Miller C; Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA., Fung J; Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA., Lo S; Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Machtay M; Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Sanabria J; Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Jazyk: angličtina
Zdroj: HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2013 Nov; Vol. 15 (11), pp. 851-7. Date of Electronic Publication: 2013 Jan 14.
DOI: 10.1111/hpb.12044
Abstrakt: Background: Surgical resection is the standard treatment for liver metastases, although for the majority of patients this is not possible. Stereotactic body radiotherapy (SBRT) is an alternative local-regional therapy. The purpose of this study was to evaluate the results of SBRT for secondary liver tumours from a combined multicentre database.
Methods: Variables from patients treated with SBRT from four Academic Medical Centres were entered into a common database. Local tumour control and 1-year survival rates were calculated.
Results: In total, 153 patients (91 women) 59 ± 8.4 years old with 363 metastatic liver lesions were treated with SBRT. The underlying primary tumour arose from gastrointestinal (GI), retroperitoneal and from extra-abdominal primaries in 56%, 8% and 36% of patients, respectively. Metastases, with a gross tumour volume (GTV) of 138.5 ± 126.8 cm(3) , were treated with a total radiation dose of 37.5 ± 8.2 Gy in 5 ± 3 fractions. The 1-year overall survival was 51% with an overall local control rate of 62% at a mean follow-up of 25.2 ± 5.9 months. A complete tumour response was observed in 32% of patients. Grade 3-5 adverse events were noted in 3% of patients.
Conclusion: Secondary liver tumours treated with SBRT had a high rate of local control with a low incidence of adverse events.
(© 2013 International Hepato-Pancreato-Biliary Association.)
Databáze: MEDLINE
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