| Autor: |
Arroyave JC; Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnológico Metropolitano, Medellín, Colombia., Pujol FH, Navas MC, Cortés-Mancera FM |
| Jazyk: |
Spanish; Castilian |
| Zdroj: |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia [Rev Chilena Infectol] 2013 Feb; Vol. 30 (1), pp. 31-41. |
| DOI: |
10.4067/S0716-10182013000100005 |
| Abstrakt: |
The human immunodeficiency virus (HIV) infection is one of the most important problems in public health. It is estimated that 3 3 million people are infected around the world. HIV and GBV-C share the same transmission route, being frequent the co-infection. Since both viruses replicate in CD4+ lymphocytes, recent studies have described an interaction. Decreasing of HIV viral load and higher CD4 counts have been observed in co-infected patients, leading a better clinical outcome. Nevertheless, some epidemiological studies have shown contradictory results. Additionally, in vitro models report inhibition of HIV by E1, E2, NS3 and NS5A GBV-C proteins, resulting in a decreasing of p24 antigen. This review summarizes the principal findings about co-infection and mechanisms that have been proposed for HIV-1 inhibition. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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