| Autor: |
Ambaye RY; Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India., Indap MA, Naik SD |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1990 May 30; Vol. 51 (2), pp. 119-25. |
| DOI: |
10.1016/0304-3835(90)90046-z |
| Abstrakt: |
alpha-[N,N-[bis(2-hydroxyethyl)]-amino]-N- (o-methoxyphenyl)pyrrolidin-2,5-dione (I), an intermediate in the synthesis of pyrrolidinedione-N-mustards, did not exhibit antitumour activity against P388 lymphocytic leukemia, Sarcoma 180 (ascites) and Ehrlich (ascites) carcinoma tumours. The effect of co-administration of (I) with established anticancer drugs was studied against these murine tumours. The activity of 5-fluorouracil against Sarcoma 180 (ascites) and Ehrlich (ascites) carcinoma was significantly enhanced by co-administration with (I). Other anticancer drugs, when co-administered with (I), did not show any enhancing effect. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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