Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins.
| Autor: | Cozen W; Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90089-9175, USA., Yu G, Gail MH, Ridaura VK, Nathwani BN, Hwang AE, Hamilton AS, Mack TM, Gordon JI, Goedert JJ |
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| Jazyk: | angličtina |
| Zdroj: | British journal of cancer [Br J Cancer] 2013 Mar 19; Vol. 108 (5), pp. 1163-7. Date of Electronic Publication: 2013 Feb 26. |
| DOI: | 10.1038/bjc.2013.60 |
| Abstrakt: | Background: Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity. Methods: We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within vs between twin pairs and by case-control status. Results: The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (P=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338 vs 369, P=0.015); this difference was not significant (169 vs 183, P=0.10) when restricted to abundant OTUs. Conclusion: In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment. |
| Databáze: | MEDLINE |
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