| Autor: |
Zyrina EV, Firstova VV, Shtannikov AV, Titareva GM, Gutova VP, Vasil'eva IS, Biketov SF |
| Jazyk: |
ruština |
| Zdroj: |
Meditsinskaia parazitologiia i parazitarnye bolezni [Med Parazitol (Mosk)] 2012 Oct-Dec (4), pp. 33-6. |
| Abstrakt: |
The immunomodulating effect of the components of an Ixodes persulcatus (Ixodidae) tick salivary gland extract (SGE) on BALB/c mice lymphocytes was evaluated. SGE of partially engorged ticks at a concentration of 50 microg/ml causes the maximum suppression ofT- and B-lymphocyte subpopulations. SGE of hungry ticks at the same concentration induces the suppression of only CD69+ T cells and TLR-2+ B cells, but produces no suppressive effect on CD69+ B lymphocytes, TLR-2+ T lymphocytes, and TLR-4+ T and B lymphocytes. SGE shows different effects on the synthesis of IFN-gamma and IL-4 by T helper cells. SGE of hungry ticks stimulated the increase of IFN-gamma and IL-4 synthesis by 4.7 and 2.6 times, respectively, as compared to the control. The findings may be of value in studying the pathogenesis of transmissible infections and in designing the vaccines based on tick gland components. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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