Residual C-peptide in patients with Type 1 diabetes and multiethnic backgrounds.

Autor:	Almeida MH; Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Nutrology Department, Rio de Janeiro/RJ, Brazil., Dantas JR, Barone B, Serfaty FM, Kupfer R, Albernaz M, Bencke MR, Zajdenverg L, Rodacki M, Oliveira JE
Jazyk:	angličtina
Zdroj:	Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2013 Jan; Vol. 68 (1), pp. 123-6.
DOI:	10.6061/clinics/2013(01)rc02
Abstrakt:	Objective: To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations. Method: Eighty-eight patients with a mean disease duration of 8.1 +7.6 years were included and underwent C-peptide measurement before and after glucagon stimulation. Chi-squared and Mann Whitney U-tests were used to compare the variables between groups (all two-tailed, α = 0.05). Spearmans correlation coefficient was used to test the association between the continuous variables. Logistic regression was used for the multivariate analysis. Twenty-eight (31.8%) individuals had significantly detectable C-peptide levels after stimuli, particularly those with a shorter disease duration (p<0.001). Results: Patients with detectable C-peptide levels required lower insulin doses (p<0.009) and had similar HbA1C results (p = 0.182) and fewer chronic complications (p = 0.029). Conclusion: C-peptide detection was common in Type-1 diabetics, particularly shortly after being diagnosed. This result may have clinical implications.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu