| Autor: |
Onesti S; Structural Biology Laboratory, Elettra-Sincrotrone Trieste, Area Science Park, Basovizza, Trieste 34149, Italy. silvia.onesti@elettra.trieste.it, MacNeill SA |
| Jazyk: |
angličtina |
| Zdroj: |
Chromosoma [Chromosoma] 2013 Mar; Vol. 122 (1-2), pp. 47-53. Date of Electronic Publication: 2013 Feb 15. |
| DOI: |
10.1007/s00412-013-0397-x |
| Abstrakt: |
The CMG (Cdc45-MCM-GINS) complex is the eukaryotic replicative helicase, the enzyme that unwinds double-stranded DNA at replication forks. All three components of the CMG complex are essential for its function, but only in the case of MCM, the molecular motor that harnesses the energy of ATP hydrolysis to catalyse strand separation, is that function clear. Here, we review current knowledge of the three-dimensional structure of the CMG complex and its components and highlight recent advances in our understanding of its evolutionary origins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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