Contribution of the inflammasomes to autoinflammatory diseases and recent mouse models as research tools.

Autor: Heymann MC; Department of Pediatrics, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany. michael.heymann@uniklinikum-dresden.de, Rösen-Wolff A
Jazyk: angličtina
Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2013 Jun; Vol. 147 (3), pp. 175-84. Date of Electronic Publication: 2013 Feb 04.
DOI: 10.1016/j.clim.2013.01.006
Abstrakt: Inflammasomes are multiprotein complexes that serve as activating platforms for the enzyme caspase-1 in response to various danger signals. Active caspase-1 can cleave the precursors of the pro-inflammatory cytokines IL-1β and IL-18 and thereby activate them. Deregulation of this cascade caused by mutations in genes coding for inflammasomal components and their interaction partners can lead to severe disease. This review summarizes the contribution of deregulated inflammasomes to the field of autoinflammatory syndromes. In addition, it gives insight into currently available mouse models that are used to study and characterize the role of the inflammasome components in the pathophysiology of these diseases.
(Copyright © 2013 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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