| Autor: |
Rajkumar DS; Department of Traumatology and Orthopedics and Battle Field Surgery, Kursk State Medical University, Karl Marx Street, Kursk 305 004, Russia., Faitelson AV, Gudyrev OS, Dubrovin GM, Pokrovski MV, Ivanov AV |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of osteoporosis [J Osteoporos] 2013; Vol. 2013, pp. 325693. Date of Electronic Publication: 2013 Jan 16. |
| DOI: |
10.1155/2013/325693 |
| Abstrakt: |
In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed that in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabeculae and in preventing the occurrence of these microfractures, as well as increasing quality of experimental fractures healing. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
