| Autor: |
Moreno-Félix C; Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, 83000 Hermosillo, SON, Mexico., Wilson-Sánchez G, Cruz-Ramírez SG, Velázquez-Contreras C, Plascencia-Jatomea M, Acosta A, Machi-Lara L, Aldana-Madrid ML, Ezquerra-Brauer JM, Rocha-Alonzo F, Burgos-Hernández A |
| Jazyk: |
angličtina |
| Zdroj: |
Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2013; Vol. 2013, pp. 273582. Date of Electronic Publication: 2013 Jan 16. |
| DOI: |
10.1155/2013/273582 |
| Abstrakt: |
Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using thin layer chromatography (TLC), and each fraction was tested for antimutagenic and antiproliferative activities. Organic extract reduced the number of revertants caused by aflatoxin B(1) showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. Based on the results obtained, the isolated fractions obtained from octopus contain compounds with chemoprotective properties that reduce the mutagenicity of AFB(1) and proliferation of cancer cell lines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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