Effector memory and late memory T cells accumulate in the blood of CMV-carrying individuals but not in their cerebrospinal fluid.

Autor: de Jongste AH; Department of Medical Oncology, Erasmus University Medical Centre/Daniel Den Hoed Cancer Centre, Groene Hilledijk 301, 3075EA, Rotterdam, The Netherlands., de Graaf MT, van den Broek PD, Kraan J, Sillevis Smitt PA, Gratama JW
Jazyk: angličtina
Zdroj: Cytometry. Part B, Clinical cytometry [Cytometry B Clin Cytom] 2013 Jul-Aug; Vol. 84 (4), pp. 218-21. Date of Electronic Publication: 2013 Feb 07.
DOI: 10.1002/cyto.b.21073
Abstrakt: Cytomegalovirus (CMV)-carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non-carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV-carrying individuals, we characterized CD4⁺ and CD8⁺ T-cell subsets in CSF and blood of both groups. Effector memory and late memory T cells were only rarely seen in CSF, which was similar in CMV carriers and non-carriers. In conclusion, there was no demonstrable difference in the numbers of CSF effector memory and late memory T cells between CMV seronegative and CMV seropositive individuals.
(Copyright © 2013 International Clinical Cytometry Society.)
Databáze: MEDLINE
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