| Autor: |
Shin EC; Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA., Park SH, Nascimbeni M, Major M, Caggiari L, de Re V, Feinstone SM, Rice CM, Rehermann B |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 2013 Apr; Vol. 87 (8), pp. 4772-7. Date of Electronic Publication: 2013 Feb 06. |
| DOI: |
10.1128/JVI.03122-12 |
| Abstrakt: |
T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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