| Autor: |
Zhang XX; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Guo SY, Li FF, Gan Y |
| Jazyk: |
čínština |
| Zdroj: |
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2012 Nov; Vol. 47 (11), pp. 1534-40. |
| Abstrakt: |
In this work, we developed PEO-PPO-PEO micelles loaded with irinotecan hydrochloride (CPT-11) using breast cancer resistance protein (BCRP) inhibitory material PEO20-PPO70-PEO20, and studied its mechanism of decreasing CPT-11 induced delayed diarrhea and intestinal toxicity. BCRP-overexpressing MDCKII (MDCKII/BCRP) cells were used to evaluate the effect of PEO20-PPO70-PEO20 and PEO-PPO-PEO micelles on transmembrane transport of CPT-11 in vitro. The biliary excretion, delayed diarrhea and intestinal damage of CPT-11 loaded PEO-PPO-PEO micelles of rats were investigated. The results showed that the obtained micelles could decrease the biliary excretion of CPT-11, ameliorate delayed diarrhea and intestinal toxicity of rats through inhibiting BCRP-mediated CPT-11 efflux. PEO-PPO-PEO micelles were promising carriers to reduce intestinal toxicity of CPTs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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