Quinolinesulfonamides of aryloxy-/arylthio-ethyl piperidines: influence of an arylether fragment on 5-HT1A/5-HT7 receptor selectivity.

Autor: Grychowska K; Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland., Marciniec K, Canale V, Szymiec M, Glanowski G, Satała G, Maślankiewicz A, Pawłowski M, Bojarski AJ, Zajdel P
Jazyk: angličtina
Zdroj: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2013 Mar; Vol. 346 (3), pp. 180-8. Date of Electronic Publication: 2013 Feb 04.
DOI: 10.1002/ardp.201200322
Abstrakt: The solid-phase synthesis of a new series of 19 biomimetics of long-chain arylpiperazines, namely flexible quinoline sulfonamides of aryl(heteroaryl)oxy-/heteroarylthio-ethyl 4-aminomethylpiperidines, is reported. Various structural modifications applied followed by biological evaluation for 5-HT1A, 5-HT6, and 5-HT7 receptors gave further support of a possible replacement of arylpiperazine with aryloxy-/arylthio-ethyl derivatives of alicyclic amines and control of receptor selectivity upon diversification in the aryl(heteroaryl)oxy-/heteroarylthio-ethyl fragment.
(Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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