| Autor: |
Pinto NV; Institute of Biomedical Sciences, State University of Ceará, Av. Paranjana, 1700, 60740-000 Fortaleza, CE, Brazil., Cavada BS, Brito LF, Pereira RI, da Silva MT, Castro RR, de Freitas Pires A, Assreuy AM |
| Jazyk: |
angličtina |
| Zdroj: |
Inflammation [Inflammation] 2013 Jun; Vol. 36 (3), pp. 713-22. |
| DOI: |
10.1007/s10753-013-9596-0 |
| Abstrakt: |
The anti-inflammatory activity of Canavalia seed lectins (Canavalia gladiata [CGL], Canavalia maritima [ConM] and Canavalia brasiliensis [ConBr]) was evaluated by intravenous administration in rats. In non-sensitized rats, cellular edema elicited by carrageenan was reduced (45-51 %) by ConM and (44-59 %) by CGL. Osmotic edema elicited by dextran was reduced by ConM and CGL in 27 % and 29 %. ConM and CGL reduced the edema elicited by L-arginine in 53 % and that of prostaglandin E2 in 48 % and 36 %. Leukocyte migration elicited by carrageenan was reduced in 49 % by ConM and in 55 % by CGL (attenuated in 4× by glucose) and peritoneal TNF-α content in 82 %. In rats sensitized, ConM inhibited the paw edema and leukocyte migration elicited by ovalbumin in 34 % and 70 %. ConM and CGL are anti-inflammatory, mainly in cellular events mediated by prostaglandin E₂, nitric oxide and TNF-α in non-sensitized rats. However, only ConM is anti-inflammatory in sensitized rats. CGL effect involves the lectin domain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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