D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.

Autor: Fieten H; Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. h.fieten@uu.nl, Dirksen K, van den Ingh TS, Winter EA, Watson AL, Leegwater PA, Rothuizen J
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2013 Jun; Vol. 196 (3), pp. 522-7. Date of Electronic Publication: 2013 Jan 31.
DOI: 10.1016/j.tvjl.2012.12.013
Abstrakt: d-penicillamine is effectively used in the lifelong treatment of copper toxicosis in Bedlington terriers and Wilson's disease in humans. A complex form of copper-associated hepatitis has recently been characterized in the Labrador retriever. The aims of this study were to evaluate the effectiveness of d-penicillamine treatment for copper-associated hepatitis in this breed, to study the effects on hepatic copper, iron and zinc concentrations, and to evaluate parameters to predict optimal duration of treatment. Forty-three client owned Labrador retrievers that were diagnosed with increased hepatic copper were treated with d-penicillamine and underwent at least one follow-up examination including a liver biopsy for histopathological scoring of inflammatory lesions. Hepatic copper, iron and zinc concentrations were determined in the initial and follow-up biopsies by instrumental neutron activation analysis. The influence of initial hepatic copper concentration, sex, age, d-penicillamine formulation and the occurrence of side effects were investigated for their influence on hepatic copper concentration after a certain period of treatment by generalized mixed modelling. d-penicillamine proved to be effective in reducing hepatic copper concentration and associated inflammatory lesions. Parameters derived from the model can be used to estimate the necessary duration of d-penicillamine treatment for Labrador retrievers with increased hepatic copper concentration. Continuous, lifelong d-penicillamine treatment is not recommended in this breed, as there may be a risk for hepatic copper and zinc deficiency.
(Copyright © 2012 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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