| Autor: |
Langenhan JM; Department of Chemistry, Seattle University, Seattle, Washington 98122, USA. langenha@seattleu.edu, Mullarky E, Rogalsky DK, Rohlfing JR, Tjaden AE, Werner HM, Rozal LM, Loskot SA |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2013 Feb 15; Vol. 78 (4), pp. 1670-6. Date of Electronic Publication: 2013 Feb 07. |
| DOI: |
10.1021/jo302640y |
| Abstrakt: |
The amphimedosides, discovered in 2006, are the first examples of naturally occurring glycosylated alkoxyamines. We report syntheses of amphimedosides A-C that feature a stereoselective oxyamine neoglycosylation and found that these alkaloids display modest cytotoxicity toward seven diverse human cancer cell lines, exhibiting IC(50) values ranging from 3.0 μM to greater than 100 μM. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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