| Autor: |
Kalitzin S; Foundation Epilepsy Institute of The Netherlans (SEIN), Heemstede, The Netherlands. skalitzin@sein.nl, Zijlmans M, Petkov G, Velis D, Claus S, Visser G, Koppert M, Lopes da Silva F |
| Jazyk: |
angličtina |
| Zdroj: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2012; Vol. 2012, pp. 1024-7. |
| DOI: |
10.1109/EMBC.2012.6346108 |
| Abstrakt: |
High frequency oscillations (HFO) in stereo electroencephalographic (SEEG) signals have been recently the focus of attention as biomarkers that can have potential predictive power for the spatial location and possibly the timing of the onset of epileptic seizures. In this work we present a case study where we compare two quantitative paradigms for automated detection of biomarkers, one based on spontaneous SEEG recordings of HFOs and the other using activity induced by direct electrical stimulation (relative Phase Clustering Index algorithm). We compare the performance of these automated methods with manually detected HFO ripples by a trained EEG analyst and explore their potential diagnostic relevance. Intracranial recordings from patients undergoing pre-surgical evaluation are processed with a combination of morphological filtering and the analysis of the auto-correlation function. The results were compared to those obtained by visual inspection and to results from an active paradigm involving stimulation with 20 Hz trains of biphasic pulses. The quantity of HFOs, estimated automatically, or "rippleness", was found to correspond to the findings of a trained EEG analyst. The relative phase clustering index (rPCI) obtained using periodic stimulation appeared to be associated with the closeness to the seizure onset zone (SOZ) detected from ictal epochs. The HFO estimates were also indicative for the SOZ but with less specificity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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