| Autor: |
Herrlich S; Institut für Mikround Informationstechnik der Hahn-Schickard-Gesellschaft e.V. (HSG-IMIT), Villingen-Schwenningen, Germany. simon.herrlich@hsg-imit.de, Spieth S, Gerstmann H, Virnich A, Zipfel F, Kitschmann A, Goettsche T, Osypka P, Zengerle R |
| Jazyk: |
angličtina |
| Zdroj: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2012; Vol. 2012, pp. 681-4. |
| DOI: |
10.1109/EMBC.2012.6346023 |
| Abstrakt: |
This paper reports on the drug release mechanisms of silicone structures with embedded steroids applied in pacing leads. Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based release control mechanisms with the target to potentially match optimal drug release rates during the first month after implantation. By incorporating dexamethasone-21-dihydrogen phosphate in silicone matrices in combination with release rate adaption layers, almost continuous release rates were obtained under physiological test settings. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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