| Autor: |
Aleksander SK, Fidler LM, Mit'kov VV, Pugachev KK, Avdeev GI |
| Jazyk: |
ruština |
| Zdroj: |
Meditsinskaia radiologiia [Med Radiol (Mosk)] 1990 Apr; Vol. 35 (4), pp. 49-52. |
| Abstrakt: |
131I- and 125I-labeled rabbit antibodies (AB) to the specific human intestinal beta 1MA were administered sc and iv to nude mice xenografts of human colon carcinoma. A study was made of the pharmacokinetics of labeled AB in the recipients' organs and tissues, measuring the radioactivity of tissue specimens on days 2, 3, 4 and 7 after injection with a gamma-counter, calculating specific radioactivity and accumulation indices. Tumors were visualized with a gamma-camera and a scanner. Proceeding from the comparison of the results of sc and iv administration of iodinated AB, a conclusion has been made of the applicability of sc injections of the agent for immunoscintigraphy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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