| Autor: |
Tel J; Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands., Aarntzen EH, Baba T, Schreibelt G, Schulte BM, Benitez-Ribas D, Boerman OC, Croockewit S, Oyen WJ, van Rossum M, Winkels G, Coulie PG, Punt CJ, Figdor CG, de Vries IJ |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer research [Cancer Res] 2013 Feb 01; Vol. 73 (3), pp. 1063-75. Date of Electronic Publication: 2013 Jan 23. |
| DOI: |
10.1158/0008-5472.CAN-12-2583 |
| Abstrakt: |
Vaccination against cancer by using dendritic cells has for more than a decade been based on dendritic cells generated ex vivo from monocytes or CD34(+) progenitors. Here, we report on the first clinical study of therapeutic vaccination against cancer using naturally occurring plasmacytoid dendritic cells (pDC). Fifteen patients with metastatic melanoma received intranodal injections of pDCs activated and loaded with tumor antigen-associated peptides ex vivo. In vivo imaging showed that administered pDCs migrated and distributed over multiple lymph nodes. Several patients mounted antivaccine CD4(+) and CD8(+) T-cell responses. Despite the limited number of administered pDCs, an IFN signature was observed after each vaccination. These results indicate that vaccination with naturally occurring pDC is feasible with minimal toxicity and that in patients with metastatic melanoma, it induces favorable immune responses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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