Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen.

Autor: Abd-Elazeim FM; Department of Dermatology and Andrology, Faculty of Medicine, Suez Canal University , Ismailia , Egypt., Mohammed GF, Fathy A, Mohamed RW
Jazyk: angličtina
Zdroj: The Journal of dermatological treatment [J Dermatolog Treat] 2014 Jun; Vol. 25 (3), pp. 264-7. Date of Electronic Publication: 2013 May 06.
DOI: 10.3109/09546634.2013.768760
Abstrakt: Background: No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW).
Objective: To evaluate the immunological mechanisms and clinical therapeutic effect of using of intralesional purified protein derivative (PPD) in the treatment of RMCW.
Methods: The study included 40 patients with RMCW. They were randomly assigned to 2 groups: first group (20 patients) received intralesional PPD antigen, and second group (20 patients) received intralesional saline as a control group. In both groups, injections were made into single lesions, or largest wart in case of multiple lesions, at weekly intervals, until complete clearance or for a maximum of six treatments. Blood serum was taken at pre-study and at week 6 to measure IL-12 level.
Results: A significant difference was found between the therapeutic responses of RMCW to PPD antigen and saline control group (p < 0.001). In the PPD group, complete response was achieved in 75% after 5.8 ± 0.7 sessions' patients presenting with RMCW. There was a statistically significant increase in IL-12 of PPD group versus saline group. No recurrence was observed in the PPD group.
Conclusion: Intralesional immunotherapy by PPD antigen is an effective and a safe treatment for RMCW in previously immunized patients.
Databáze: MEDLINE
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