High HIF-1α expression genotypes in oral lichen planus.

Autor: de Carvalho Fraga CA; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., Alves LR, Marques-Silva L, de Sousa AA, Jorge AS, de Jesus SF, Vilela DN, Pinheiro UB, Jones KM, de Paula AM, Guimarães AL
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2013 Dec; Vol. 17 (9), pp. 2011-5. Date of Electronic Publication: 2013 Jan 19.
DOI: 10.1007/s00784-013-0920-8
Abstrakt: Objective: The aim of this study is to assess whether C1772T and G1790A hypoxia-inducible factor-1 (HIF-1)α polymorphisms are associated with risk of oral lichen planus (OLP).
Material and Methods: Restriction fragment length polymorphism analysis was used to investigate HIF-1α C1779T and G1790A polymorphisms in 32 OLP and 88 individuals without OLP.
Results: The frequency of the CC, TT, GA, and AA genotypes was higher in patients with OLP. Notably, individuals carrying the C and A, and T and A haplotypes showed a significant association OLP risk.
Conclusions: Our study demonstrated that the C1772T and G1790A polymorphisms of HIF-1α gene increased the risk of OLP. C1772T and G1790A polymorphisms of HIF-1α gene had differing patterns of allelic imbalance in the normal samples and subsequent chronic lesions. Further studies are necessary to elucidate the HIF-1α pathway in OLP, which would facilitate the development of novel therapeutic strategies for the prevention and treatment of OLP.
Clinical Relevance: These results, in conjunction with previous studies, suggest that HIF-1α may play important roles in the chronicity of oral mucosa lesions of OLP patients. Taken together, we suggest that HIF-1α polymorphisms enhance its target genes, thereby altering the microenvironment and supporting sequential release of inflammatory mediators or cellular events in OLP. It appears unlikely that inhibition of a single proinflammatory mediator will prove useful in clinical practice, but several ways to reprogram mediators engaged in a wide array of roles simultaneously are encouraging.
Databáze: MEDLINE
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